Primum Non Nocere

First, do no harm.  Sounds easy enough, but have you ever ordered a “screening CT?”  Have you ever been “better safe than sorry?”  We’re all aware of the nebulous risk of radiation from the imaging we order, we know that getting stuck for blood hurts, and sometimes medications have side effects, but what happens when the results of tests themselves are the things harming patients?

This article does a great job exploring this question.  I’ve also found patients much more receptive to my explanations as to why I’m not ordering the thing they think they need since reading this and spending some time thinking about it.  There are definitely times when my honest indication for ordering that Head CT is “patient wants it…” but in general this article has pushed me a little closer to the minimalists’ corner.

Overkill – Atul Gawande

How Evidence Based Are We?

Here is a pretty comical article by Dr Ioannidis. If you do not know who this is stop now and read this.

This article was just published. It is written as a report to the father of evidence based medicine, Dr David Sackett. It takes a not terribly optimistic view of the current state of medical research. He calls out industry bias, ghost authorship, and many other flaws of our system. We are very lucky to have people like Dr Ioannidis ensuring integrity to the research process.

Managing Migraine

As mentioned on R and R in the Fast Lane. This article by Friedman is a welcomed update to evidence-based migraine management. Some people love treating migraine patients, some hate it. But we all have our cocktails we believe in.

I am a fioricet/neurontin/IM compazine, escalating to IV compazine/benadryl/decadron/toradol OR if they want to drive home IV MAG/decadron/toradol … kind of guy.

This article starts with criteria for delineating migraine from other headache forms. Then provides a succinct algorithm for treatment, starting with reglan or compazine +/- benadryl, then another dose plus toradol, then dihydroergotamine, then occipital nerve blocks (very fun), then as a last resort, opioids. I would encourage you to attempt a few other methods before the blocks and especially before the opioids.

Many other medications can be used (keppra, depakote, propofol, etc). But this is a solid overview of the EM approach. Also of note, see the Oct 2016 EM-RAP paper chase of the reglan +/- IV fluids in migraine article which showed no real benefit to the addition of IVF.

Head injury patients with delayed presentation to ED

Another pearl from EM Lit of Note. Bottom line: Retro review of CT head obtained for trauma divided into <24 hours and >24 hours time of presentation. The delayed presenters had a HIGHER percentage of positive CT and had a similar amount of patients requiring NES intervention.

We discussed this the other day. First Care obtained a head CT on a patient several days after a minor head injury. We presumed it was not indicated. Then I read this paper.

Unfortunately I cannot find in the paper a description of time to presentation. It is grouped into less than 24 hours and greater than. I wonder if the likelihood of positive CT scan decreases as time from injury to presentation increases.

In any event, this poses difficult questions. Should we obtain more CTs on the delayed presenters? They are as likely to have positive findings. In addition, the NICE guideline is 70% sensitive, versus its comforting 98% in the less than 24 hour group.

Would be a good article to discuss for journal club. Would love to see some comments.

Approach to PE

Hey all,
I got the privilege of going to ACEP last week in Boston. When I got the schedule one of the lectures that stood out to be was a PE lecture by Jeffrey Kline. Some of you may recognize the name but if not, he is an attending at IU with a special interest in thromboembolism. He is very active on twitter at @klinelab and wrote the Thromboembolism chapter in Tintinalli’s. After talking about PE last month and specifically approach to PE in the pregnant patient, I thought a summary of the key points would make for a worthwhile post.

The first question in the discussion of VTE should be ‘who actually needs to be tested?’ If someone comes in complaining of recent chest pain or dyspnea, PE needs to be included in the differential. If they are not complaining of those recently and have normal vitals (at all times) then you don’t need to go chasing down a clot that isn’t there. If the patient does complain of those then some sort of documentation is required to show you considered a PE. Even stating ‘I think PE is unlikely because of X, Y and Z’ would likely be enough. Now if your pretest probability is anything other than very low, some combination of wells, perc, Geneva should be applied. I like the following algorithm which I think Kline discussed on EMRap towards the end of last year.
algo

Following that algorithm helps cut down on the number of ct scans you’ll order, cuts down your false-positives, radiation exposure, and contrast induced nephropathy without increasing the number of significant PE’s that you miss.

As far as the pregnant patient, I think everyone knows to start with the lower extremity ultrasounds in hopes of an answer that would let you initiate treatment. However, when that is inevitably negative, there is also an algorithm for that scenario that incorporates a trimester adjusted d dimer.

algopreg

The other main takeaway from this talk was the disposition change on some of the low risk patients. Dr. Kline said he has sent about 70 patients home from the ED after being diagnosed with PE. To stratify who falls into low risk, you can apply the sPESI or HESTIA score as well as who is at low risk of bleeding.

–Simplified PESI-if any +, pt is NOT low risk:
age greater than 80
history of cancer
history of chronic cardiopulmonary disease
pulse greater than 100
BP less than 100
O2 sat less than 90

–Hestia-pt CAN BE considered low risk if
BP greater than 100
No thrombolysis needed
No active bleeding
02 sats greater than 90
Not already anticoagulated
No other medical or social reason for admission
Cr clearance greater than 30
not pregnant, no severe liver disease

For these people they’ll initiate rivaroxaban or apixaban in the ED and send them home with a prescription. The only failures they’ve experienced are people who returned requiring additional pain management. Has anyone done this or considered it? The majority of our patient population would not satisfy these requirements or, frankly, be reliable enough to consider outpatient management, but what about people working in the community with a different population?

Lastly, we all know to look for S1Q3T3 on the ekg to raise suspicion for PE but the odds ratio is only 2.06. Inverted T’s in V2 and V3 have odds ratios of 6.94 and 7.07 respectively, and are the most SPECIFIC ekg finding in pulmonary embolism

2015 ACLS GUIDELINES

The new 2015 ACLS guidelines were published this month!  I love new guidelines!  I’ve highlighted the important drug stuff (you guys are on your own for the rest).

Vasopressin: REMOVED FROM ALGORITHM: This was no surprise to me as vasopressin has never been shown to offer any advantage over epinephrine in studies to date.

“Vasopressin offers no advantage as a substitute for epinephrine in cardiac arrest (Class IIb, LOE B-R)”

“Vasopressin in combination with epinephrine offers no advantage as a substitute for standard-dose epinephrine in cardiac arrest (Class IIb, LOE B-R)”

Steroids: I’ve been skeptical of the use of steroids in cardiac arrest since 2009 inhospital cardiac arrest trial (steroids were combined with a vasopressor bundle or cocktail of epi and vasopressin).  Will need much more convincing data before I’ll recommend routine use- and that is exactly what our guidelines endorse as well.  Because: no one in the ICU dies before receiving a course of steroids.  The pre-hospital use of steroids is pretty clear: no benefit.

“In IHCA, the combination of intra-arrest vasopressin, epinephrine, and methylprednisolone and post-arrest hydrocortisone as described by Mentzelopoulos et al may be considered; however, further studies are needed before recommending the routine use of this therapeutic strategy (Class IIb, LOE C-LD)”

“For patients with OHCA, use of steroids during CPR is of uncertain benefit (Class IIb, LOE C-LD)”

Epinephrine: Nothing groundbreaking here.  A few trials did demonstrate ROSC advantage with high-dose epi over standard dose; however, no improvement in survival to discharge (emphasis on good neurologic recover) over standard dose.  There is much concern with adverse effects of higher dose epi in the post-arrest period which may negate potential advantages during intra-arrest period.

“Standard-dose epinephrine (1 mg every 3 to 5 minutes) may be reasonable for patients in cardiac arrest (Class IIb, LOE B-R)”

“High-dose epinephrine is not recommended for routine use in cardiac arrest (Class III: No Benefit, LOE B-R)”

Antiarrhythmics: Really no changes.  Emphasized use of amiodarone over lidocaine (which is not new).

“Amiodarone may be considered for VF/pVT that is unresponsive to CPR, defibrillation, and a vasopressor therapy (Class IIb, LOE B-R)”

“Lidocaine may be considered as an alternative to amiodarone for VF/pVT that is unresponsive to CPR, defibrillation, and vasopressor therapy (Class IIb, LOE C-LD)”

“The routine use of magnesium for VF/pVT is not recommended in adult patients (Class III: No Benefit, LOE B-R)”

Circulation 2015:132:S444-64

NEXUS in the Elderly

Hopefully everyone is using the NEXUS criteria or the Canadian C Spine rule in evaluation of patients who have undergone neck trauma. Those familiar with both know one major difference, age criteria. NEXUS does not use age, Canadian C spine does. Using both rules together, like PERC with Well’s, increases sensitivity at expense of specificity.

Well here is a study on falls in the elderly (i.e. low mechanism which is another difference between NEXUS and Canadian) and application of NEXUS. Turns out, probably shouldn’t be using NEXUS in patients over 65. Liberally scan these folks, radiation is less of a concern, and the cost is justified due to morbidity of missed injuries. And of course do not bother with plain films (in adults).

Hot off the Press, Droperidol is Still Safe

Yet another quality article illustrating the safety of the most magical drug, droperidol. Not sure where people are getting it, as it is not being manufactured currently. We have none at any of my hospitals in Louisville. It is sad but perhaps someday we will get it back. In the same Annals issue an indictment of professional societies, journal editorial boards, and government advisory committees with their misinterpretation of “so-called facts.” Great reading, Dr Newman is the man.

Predators

Great discussion of the biases and conflicted interests of medical publication. Here is a fun little news story about one of the predatory journals, which we didn’t even get into. Looking forward to another conference dedicated to reading the literature.

I also meant to introduce everyone present to Belinda Yff, our medical librarian. Not only is she invaluable for assistance with literature search, but she completely caters to the Emergency Physician’s unrealistic expectations of rapid results. She completes and sends me literature searches in a matter of minutes to hours, and can borrow articles from other libraries when we do not have access.

I would strongly recommend everyone saving Belinda’s information and asking for her help with research interests and lecture preparation. Her email address is belinda.yff@louisville.edu.

ACEP’s Choosing Wisely campaign

Here’s an excerpt from our ED-Public Health website (http://www.edpublichealth.com):

ACEP’s contributions to the Choosing Wisely Campaign

At ACEP13 last October in Seattle, the organization announced its 5 contributions to the Choosing Wisely Campaign. Initially started by the American Board of Internal Medicine (ABIM) Foundation, the Choosing Wisely Campaign was a response to the movement towards improved healthcare efficiency and a need to decrease unnecessary/low-value procedures and tests. Despite ACEP’s original reluctance to join, in February 2013 ACEP jumped on board and began creating their list of recommendations. After extensive review by an expert panel of emergency physicians and the ACEP Board of Directors, ACEP’s Choosing Wisely recommendations were released.1,2 They include:

1. Avoid Head CTs in ED patients with minor head injury who are at low risk based on validated decision rules.
2. Avoid placing indwelling urinary catheters in the ED for either urine output monitoring in stable patients who can void, or for patient or staff convenience.
3. Don’t delay engaging available palliative and hospice care services in the ED for patients likely to benefit.
4. Avoid antibiotics and wound cultures in ED patients with uncomplicated skin and soft tissue abscesses after successful incision and drainage and with adequate medical follow-up.
5. Avoid instituting IV fluids before doing a trial of oral rehydration therapy in uncomplicated ED cases of mild or moderate dehydration in children.

You be the judge.
Here is a list of pros and cons formulated based on literature review, articles and editorials from other emergency physicians (EPs).

Pros:
1. Reduce cost without affecting quality of care.1,2
2. Improve efficiency.1,2 Example: shorter LOS if imaging is involved
3. Encourages shared decision-making between patients and physicians.1,2,8
4. Medical benefits: Less ionizing radiation exposure, less risk of antibiotic-resistant organisms, fewer catheter-associated UTIs.1,2,4
5. EP-generated, EP-approved. EPs are identifying “low value” procedures/tests for their own speciality, rather than letting others define these for us.1,2,6 For example: the proposed, but ultimately rejected, CMS “use of Brain CT in the ED for atraumatic headache” measure was created by CMS without EP input.8

Cons:
1. Lack of advocacy for medical liability reform.1,2,5
2. EPs have no right of refusal to our patients.5
3. EPs often pick up the slack for other doctors.5
4. Will it come to a point where these 5 tests/procedures will be uncompensated?5
5. Loss of autonomy.6

Other lists of over-used and “low value” tests exist out there. Most notable is a list of 5 tests which was created by EPs and mid-level providers from six Partners Healthcare hospitals near Boston. Published in JAMA, this list was designed to be “actions a specialty provider”7 can take.6,7 They include:

1. Do not order CT of the C-spine for patients after trauma who do not meet NEXUS low risk criteria or the Canadian C-spine Rule.
2. Do not order CT to diagnose PE without first risk stratifying for PE (pretest probability and D-dimer tests if low probability). (included in ACR’s Choosing Wisely list)3,4
3. Do not order MRI of the L-spine for patients with lower back pain without high-risk features. (included in AAFP’s and ACP’s Choosing Wisely list)3,4
4. Do not order CT of the Head for patients with mild traumatic head injury who do not meet New Orleans criteria and Canadian CT Head Rule.
5. Do not order coagulation studies on patients without hemorrhage or suspected coagulopathy (eg: with anticoagulation therapy, clinical coagulopathy)

ACR = American College of Radiology, AAFP = American Academy of Family Physicians, ACP = American College of Physicians

Bedside actions: to begin incorporating these EP-approved recommendations into our daily practice in an effort to institute cost-effective quality medical care (ideally before private insurers, CMS, or other specialty societies begin mandating us to do the same)

References:
1. ACEP Announces List of Tests as Part of Choosing Wisely Campaign. ACEP Clinical & Practice Management. October 14, 2013. Downloaded from http://www.acep.org/Clinical—Practice-Management/ACEP-Announces-List-of-Tests-As-Part-of-Choosing-Wisely-Campaign/.
2. ACEP Prepares List for Choosing Wisely Campaign. ACEP Clinical & Practice Management. Downloaded from http://www.acep.org/Clinical—Practice-Management/ACEP-Announces-List-of-Tests-As-Part-of-Choosing-Wisely-Campaign/.
3. Choosing Wisely Master List. www.choosingwisely.org. Downloaded from http://www.choosingwisely.org/wp-content/uploads/2013/02/Choosing-Wisely-Master-List.pdf.
4. Mahesh, M. and Durand, D.J. The Choosing Wisely Campaign and its Potential Impact on Diagnostic Radiation Burden. J Am Coll Radiol. 2013; 10(1): 65-6.
5. Seaberg, David. Pro/Con: Why ACEP Should Not Join the ‘Choosing Wisely’ Campaign. Emergency Physicians Monthly. Published August 24, 2012. Downloaded from http://www.epmonthly.com/features/current-features/the-wiser-choice-should-acep-join-the-choosing-wisely-campaign-no/.
6. Schuur, J.D., Carney, D.P., Lyn, E.T., Raja, A.S., Michael, J.A., Ross, N.G., and Venkatesh, A.K. A Top-Five List of Emergency Medicine: A pilot project to improve the value of emergency care. JAMA Intern Med. 2014; 174(4): 509-515.
7. The Tale of Two Lists: Procedures to Avoid in the ED. Acute Care, Inc. Published February 25, 2014. Downloaded from http://www.acutecare.com/the-tale-of-two-lists-procedures-to-avoid-in-the-ed.
8. Venkatesh, A.K. and Schuur, J.D. A “Top Five” list for emergency medicine: a policy and research agenda for stewardship to improve the value of emergency care. American Journal of Emergency Medicine. 31 (2013) 1520-1524.

 

Post-Publication Peer Review

For those who have not been introduced to this concept, here is a blog post from Dr Radecki who writes the EM Lit of Note.

Because blog posts are not “peer-reviewed” before they are posted, the quality of a given post could be low. But depending on how many people read the post, the discussion can be lively and constructive.

This is in contrast to formal journal publication, where the peer review is PRE-publication, and discussion may be minimal. We will see a comment or two in an issue a month or two later, sometimes an official comment in the same issue. But the volume and even quality of responses possible with blogs, twitter, etc may surpass that of the official, slow process in the journals.

Scientific American had a nice article about this PPPR concept. As FOAMed and social media continues to expand in medicine, and in other fields, I think we will see more respect for this type of peer-review.

Routine Coags in Chest Pain

Thought this was a great little post regarding Coagulation studies in chest pain patients. Not sure how often its getting routinely obtained on our CP patients @ UofL but at Norton they get it on almost every chest pain patient that rolls through the door.
We’ve reduced the amount of coag studies we’re getting on our routine trauma patients, probably about time we make sure we’re doing the same in our low-risk chest pain patients.

What Emergency Physicians Can Do to Reduce Unnecessary Coagulation Testing in Patients with Chest Pain