Syphilis in the Emergency Department

There is rarely a shift in the emergency department where we aren’t asked to evaluate an STI-related complaint.  We frequently test for gonorrhea, chlamydia, and trichomoniasis, and we frequently treat for these as well. While the vast majority of these cases are not “emergencies” per se, we recognize how important to public health these diseases can be. Occasionally, I’ve seen people test for hepatitis if there’s an unexplained jaundice, right upper quadrant pain, or GI upset. However, there are two STI’s which we don’t frequently test for in the department, namely HIV and syphilis. Despite their clear dangers to public heath, we don’t test for these often. I’ve heard people give different reasons for this. “We aren’t primary care”, “they can just go to the health department”, or “I don’t want to have to wait on those tests” are some of the most common. We’ve touched on HIV testing at room9er previously, so I’ll limit this post to syphilis and what we can do in the Emergency Department.

Syphilis, which can cause significant morbidity and mortality, has been increasing in prevalence in recent years. In Louisville, there were 73 cases diagnosed in 2014. In 2016, this number increased to 89. There are many different factors that contribute to this, including decreased condom use, availability of new partners on dating apps, and cuts to public health initiatives and clinics. Regardless of the cause, syphilis rates are increasing and we undoubtedly have seen patients who are affected by it during our residency.

Risk factors for syphilis are similar to those of other STI’s. Men who have sex with men, those with multiple sexual partners, patients diagnosed with other STI’s including HIV, pregnant women, patients taking pre-exposure prophylaxis for HIV, and those with partners known or suspected to have syphilis are at increased risk.

So what can we do if a patient comes in with a chief complaint of GU discomfort or STI exposure? Firstly, we need to think about all of the potential diseases, not just the ones we routinely treat such as gonorrhea and chlamydia. Evaluate for risk factors during the history. Look for chancres or other sores during the GU exam, and test and treat as necessary. For those with known exposure, empiric treatment is recommended  by the CDC.  For patients presenting with known exposure, primary, or secondary syphilis,  benzathine penicillin G, 2.4 million units IM is currently recommended. Alternative regimens exist for those who have allergies to penicillin. In other words, testing and treatment are relatively simple and straightforward in the early stages.

If a patient is high-risk, please resist the urge to pass the tasks of testing and treating to their primary doctor. Many of our patients have poor follow up and do not understand the threat this disease poses to public health.

My Lesson on Anchoring

If I had to pick one case from intern year that truly taught me the importance of keeping a wide differential diagnosis, it would be my final Room 9 of the year. The buzzer went off, and as I made my way to the trauma bays, I was able to get a brief rundown from the attending. “Seizure, 40-sish male, no known history”. OK, this was something I could do. I began running everything I’d need to do through my head as I prepared for the patient. “ABC’s. Vitals. Fingerstick glucose. Ativan… Could be trauma, hypoglycemia, benzo or alcohol withdrawal…” As I was refining my differential, the patient came in. The patient was non-rhythmically jerking, was not responsive to voice or sternal rub. I noticed he was wearing dress pants and a collared shirt. He was breathing spontaneously and maintaining sats in the mid 90’s. Palpable pulses and good heart sounds. Glucose was in the 100’s. EMS said he had been found like this approximately fifteen minutes prior, and his clinical status hadn’t changed since then. No known medical history or medicines.  I called out for the nurse to draw up Ativan, as I said this I noticed the patient had urinated on himself. Everything in my mind pointed towards a seizure. I grabbed the otoscope to perform the secondary survey and pried open his eyes. That’s when I felt the rug come out from under me.

The patient had pinpoint pupils, one millimeter bilaterally. The attending and I immediately had the same thought, and as I opened my mouth I heard him say, “let’s get some narcan for this guy!” The narcan got administered quickly, and soon after the patient woke up agitated, but responsive. His family had driven to the ED soon after he arrived, so questioning him was difficult. We ended up taking him to privacy in an empty x-ray room, where he admitted to using heroin earlier in the day. Sure enough, his toxicology screen was positive for opiates. We counseled him, observed him in the ED to ensure he didn’t need another dose, and then discharged him home.

What struck me about this case was that while I had formulated a differential, I had done so after anchoring to a faulty premise. It taught me a valuable lesson in keeping my differential broad, and it’s a lesson I’ll carry to every patient encounter from here on out.